Process for sultamicillin intermediate
AssigneePfizer Inc.
InventorsDennis M. Godek, Thomas A. Morris
Life of this patent
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Abstract
A simplified method for making the chloromethyl ester of sulbactam in which the tetraalkylammonium sulbactam salt is not dried and isolated prior to alkylation. The method comprises reacting a tetraalkylammonium salt and a sulbactam salt in an aqueous solution to form an aqueous solution of tetraalkylammonium sulbactam. The tetraalkylammonium sulbactam is extracted into bromochloromethane or iodochloromethane, and water is removed from the organic layer to enhance the formation of the chloromethyl ester of sulbactam. The tetraalkylammonium sulbactam is reacted with bromochloromethane or iodochloromethane in the organic layer to form the chloromethyl ester of sulbactam.
Claims9
A method for making the chloromethyl ester of sulbactam comprising:
- a) contacting a tetraalkylammonium salt and a sulbactam salt in an aqueous solution to form an aqueous solution of tetraalkylammonium sulbactam;
- b) combining said aqueous solution of tetraalkylammonium sulbactam and bromochloromethane or iodochloromethane to form an aqueous and an organic layer;
- c) separating said layers;
- d) removing water from said organic layer to enhance the formation of the chloromethyl ester of sulbactam;
- and
- e) allowing said tetraalkylammonium sulbactam to react with the bromochloromethane or iodochloromethane, in said organic layer, to form the chloromethyl ester of sulbactam.
Dependencies are inferred from the claim text.