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US 5,399,676 AGranted
Oligonucleotides with inverted polarity
AssigneeGilead Sciences, Inc.
InventorBrian Froehler
Life of this patent
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Abstract
Oligonucleotides having tandem sequences of inverted polarity, i.e., oligonucleotides comprising regions of the formula: ##STR1## wherein --C-- symbolizes any method of coupling the nucleotide sequence of opposite polarity, are useful for forming an extended triple helix with a double-helical nucleotide duplex. The inverted polarity also stabilizes the single-strand oligonucleotides to exonuclease degradation.
Claims32
An oligonucleotide comprising
- a first nucleotide sequence containing at least three nucleotide residues, said sequence having either 3'.fwdarw.5' or 5'.fwdarw.3' polarity, and, coupled thereto,
- a second nucleotide sequence containing at least three nucleotide residues, said second sequence having polarity inverted from that of the first sequence.
Dependencies are inferred from the claim text.