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US 5,399,667 AGranted
Thrombospondin receptor binding peptides
AssigneeWashington University
InventorsWilliam A. Frazier, Minh D. Kosfeld
Life of this patent
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Abstract
Novel short peptides are disclosed that bind to the thrombospondin 1 receptor, which preferably have 5-13 amino acid residues which share the tripeptide Val-Val-Met and have the following sequences: RFYVVMWKQVTQS (Seq ID No. 1) and fragments thereof containing the minimal sequence RFYVVM, (Seq ID No. 3) and FIRVVMYEGKK (Seq ID No. 4) and fragments thereof containing the minimal sequence IRVVM (Seq ID No. 5).
Claims8
A VVM-containing peptide that binds to the thrombospondin 1 receptor selected from the group consisting of:
- RFYVVMWKQVTQS (Seq ID No. 1) and fragments thereof containing at least the sequence RFYVVM (Seq ID No. 3), and
- FIRVVMYEGKK (Seq ID No. 4) and fragments thereof containing at least the sequence IRVVM (Seq ID No. 5).
Dependencies are inferred from the claim text.