US 5,399,584 A · Use of flavone derivatives for gastroprotection

Abstract

The subject invention relates to methods for preventing or treating damage to the mucosal lining of the gastrointestinal tract of a human or lower animal by administering a safe and effective amount of a compound having the structure: ##STR1## wherein X and Y are each independently selected from O and S; R.sup.1, R.sup.2 and R.sup.3 are each independently selected from hydrogen, hydroxy, halo, unsubstituted or monosubstituted straight or branched C.sub.1 -C.sub.4 alkanyl, and unsubstituted or substituted straight or branched C.sub.1 -C.sub.4 alkanoxy; and each of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is hydrogen or, if one or more of R.sup.1, R.sup.2 and R.sup.3 is other than hydrogen, each of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is selected from hydrogen, halo, trifluoromethyl, and unsubstituted straight or branched C.sub.1 -C.sub.4 alkanyl.

Claims19

Dependent claims

A composition useful for prevention or treatment of damage to the mucosal lining of the gastrointestinal tract of a human or lower animal comprising:

1) a safe and effective amount of a compound having the structure:
##STR10## wherein a) X is independently O or S;
b) R.sup.1 is selected from the group consisting of hydrogen, fluoro, methoxy and carboxymethoxy and its methyl and ethyl esters;
R.sup.2 is selected from the group consisting of hydrogen, methoxy, ethoxy, methyl, carboxymethoxy and its methyl and ethyl esters;
and furthermore either, but not both, R.sup.1 or R.sup.2 is hydrogen or both R.sup.1 and R.sup.2 are methoxy;
c) R.sup.3 is selected from the group consisting of hydrogen, hydroxy, methoxy, methyl, chloro and fluoro;
and
d) R.sup.4, R.sup.5 and R.sup.6 are all hydrogen;
or if one of R.sup.1 and R.sup.2 is other than hydrogen;
R.sup.4 is selected from the group consisting of hydrogen, fluoro, chloro and trifluoromethyl;
R.sup.5 is hydrogen;
R.sup.6 is selected from the group consisting of hydrogen, fluoro and chloro;
and
e) no more than two of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are other than hydrogen;
and
2) a pharmaceutically-acceptable carrier.

13 more elements

Dependencies are inferred from the claim text.

Use of flavone derivatives for gastroprotection

Life of this patent

Use of flavone derivatives for gastroprotection

Life of this patent

Abstract

Claims19