Isoxazole derivatives and salts thereof
AssigneeTaiho Pharmaceutical Co., Ltd.
InventorsTakashi Shindo, Naosuke Matsuura, Naohiko Ono, Yushiro Akizawa, Kenji Nozaki, Masahiro Suzuki
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Abstract
An isoxazole derivative represented by the general formula (1) or a salt thereof: ##STR1## a method for preparing the same; compositions for inhibiting lipoxygenase and cyclooxygenase comprising an effective amount of the derivative and a pharmaceutically acceptable carrier therefor; and a method for inhibiting lipoxygenase and cyclooxygenase which comprises administering to a patient the derivative.
Claims16
An isoxazole derivative represented by the general formula (1) or a salt thereof, ##STR62## wherein R and R.sup.1 are the same or different and each is a hydrogen atom, a lower alkyl group, a lower alkoxy group or a halogen atom;
- m is 0 to 5;
- A is --NH--, --O-- or a direct bond;
- B is --C(.dbd.Z)--NH--,--C(.dbd.Z)--(CH.dbd.CH).sub.l -- or --CH.dbd.CH-- (wherein Z is an oxygen or sulfur atom and l is 0 to 2;
- provided that when m is 0 and A is a direct bond and Z is an oxygen atom, l is not 0);
- X is a nitrogen or carbon atom;
- n is 0 to 3;
- and Y is a hydroxy group, a lower alkoxy group, a lower alkyl group, a lower alkoxycarbonyloxy group, a lower alkoxycarbonylmethyloxy group, a carboxylmethyloxy group, an amino acid residue which may have a protective group, a lower alkylcarbonyloxy group, a pyridylcarbonyloxy group, a dimethylaminophenylcarbonyloxy group or a di-lower-alkyl phosphate residue;
- provided that when n is 2 or 3, the two or three Ys are the same or different and each is one of the groups mentioned above, that when n is 2 or more, two Ys may form a methylenedixoy group, that when X is a nitrogen atom, n is 0 and that when A is --NH--, m is 1 to 5.
Dependencies are inferred from the claim text.