Aspartic acid derivatives, and their use for inhibiting platelete aggregation

Aspartic acid derivatives of the general formula I ##STR19## in which X denotes ##STR20## A denotes --(CH.sub.2).sub.m --, --O-- or a direct bond, k=2 or 3

• m denotes a number from 0 to 4
• R denotes ##STR21## R.sup.1 denotes hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, phenyl, where the C.sub.1 -C.sub.6 alkyl, the C.sub.3 -C.sub.8 cycloalkyl or the phenyl is unsubstituted or mono- or di-substituted by identical or different radicals selected from the group consisting or hydroxyl, carboxyl, C.sub.1 -C.sub.4 alkoxycarbonyl, phenylmethoxycarbonyl, carboxamido, C.sub.1 -C.sub.4 alkylaminocarbonyl, amine, mercapto, C.sub.1 -C.sub.4 alkoxy, C.sub.3 -C.sub.8 cycloalkyl, imidazolyl, indolyl, pyrrolidinyl, hydroxypyrrolidinyl, halogen, phenyl or phenoxy, each of which is unsubstituted or monosubstituted or di-substituted by hydroxyl, C.sub.1 -C.sub.4 alkyl, halogen, nitro or trifluoromethyl;
• R.sup.2 and R.sup.3 independently of one another denote hydrogen or R.sup.1 ;
• R.sup.4 denotes the radical of an amine acid selected from the group consisting of Aad, Abu, .beta.Abu, ABz, 2ABz, .epsilon.Aca, Ach, Acp, Adpd, Ahb, Aib, .beta.Aib, Ala, .beta.Ala, .DELTA.Ala, Alg, All, Ama, Amt, Ape, Apm, Apr, Arg, Asn, Asp, Asa, Aze, Azi, Bai, Bph, Can, Cit, Cys, (Cys).sub.2, Cyta, Daad, Dab, Dadd, Dap, Dapm, Dasu, Dien, Dpa, Dtc, Fel, Gln, Glu, Gly, Guy, hAla, hArg, hCys, hGln, hGlu, IIis, hIle, hLeu, hLys, hMet, hPhe, hPro, hScr, hThr, hTrp, hTyr, Hyl, Hyp, 3Hyp, Ile, Ise, Iva, KVn, Lant, Lcn, Leu, Lsg, Lys, .beta.Lys, .DELTA.Lys, Met, Mim, Min, nArg, Nle, Nva, Oly, Orn, Pan, Pec, Pen, Phe, Phg, Pic, Pro, .DELTA.Pro, Pse, Pys, Pyr, Pza, Oin, Ros, Sar, Sec, Sem, Ser, Thi, .beta.Thi, Thr, Thy, Thx, Tia, Tle, Tly, Trp, Trta, Tyr, Val, Tbg, Npg, Chg, Cha, Thia, 2,2-diphenylaminoacetic acid, 2- (tolyl)-2-phenylaminoacetic acid, 2-(p-chlorophenyl) aminoacetic acid, or of a dipeptide thereof, in which the peptide bond can also be reduced to --NH--CH.sub.2 --, and their physiologically tolerable salts.