Benzylidenequinuclidinones
AssigneeMerck Patent GmbH
InventorsIngeborg Stein, Roland Martin, Michael Casutt, Ulrich Heywang, Henning Bottcher, Gunther Holzemann
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Abstract
The invention relates to benzylidene-quinuclidinone derivatives of the formula I ##STR1## in which R.sup.1 is A; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are in each case independently of one another H, A, OA or OH; and A is a straight-chain or branched alkyl radical having 1 to 10 C atoms and processes for their preparation and their use in cosmetic and/or pharmaceutical preparations.
Claims13
A benzylidenequinuclidinone compound of the formula I ##STR4## in which R.sup.1 is A;
- R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are in each case independently of one another H, A, OA or OH;
- and
- A is a straight-chain or branched alkyl radical having 1 to 10 C atoms;
- and salts thereof, with the proviso that together R.sup.1 is not methyl and R.sup.3 and R.sup.5 are not methoxy;
- and benzylidene is not monomethoxy, dimethoxy, or monoethoxy.
In a method of protecting human epidermis or hair against UV rays, the improvement comprising administering an effective amount of a compound of formula I ##STR5## in which R.sup.1 is A;
- R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are in each case independently of one another H, A, OA or OH;
- and
- A is a straight-chain or branched alkyl radical having 1 to 10 C atoms;
- and salts thereof.
A method for the treatment of inflammation and/or allergies of the skin, comprising administering an effective amount of a compound of formula I ##STR6## in which R.sup.1 is A;
- R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are in each case independently of one another H, A, OA or OH;
- and
- A is a straight-chain or branched alkyl radical having 1 to 10 C atoms;
- and salts thereof.
Dependencies are inferred from the claim text.