Pharmaceutical compositions

An oral pharmaceutical composition in the form of a tablet comprising (i) a fat granulate containing from about 2 milligrams to about 5.5 milligrams of ketotifen or acid addition salt thereof in a lipophilic matrix comprising cetyl palmitate or glyceryl fatty acid esters;

• (ii) a placebo granulate containing lactose and one or more components selected from the group consisting of starch, cellulose ethers and polyvinylpyrrolidone;
• and (iii) a film coating covering the fat granulate and placebo granulate and said granulates containing an outer lubricant phase comprising magnesium stearate, wherein said film coating comprises 0.1 to 25% by weight based on total weight of said composition and wherein the the weight ratio of said fat granulate to said placebo granulate is from about 1:0.1 to about 1:1, the weight ratio of said ketotifen to said lipophilic matrix is 1:10 to about 1:30, said composition is in a unit dosage form for once-a-day oral administration, and all ingredients in said composition are pharmaceutically acceptable.