Process for making a hard-candy based oral pharmaceutical lozenge containing an antacid
AssigneeMcNeil-PPC, Inc.
InventorsThomas S. Ells, Joseph R. Luber
Life of this patent
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Abstract
A hard candy based lozenge containing an antacid is produced in a manner compatible with a continuous process method of manufacture. Sucrose solution, corn syrup, and a carbonate antacid are mixed, the mixture is heated, the mixture is further heated and exposed to a vacuum. The mixture is then mixed with cold-flow enhancers, flavorings, and colorings, and finally tempered and formed into lozenges of exceptional efficacy and taste. The lozenges thus formed contain 600 mg of calcium carbonate or magnesium carbonate.
Claims17
A process for manufacturing a hard-candy lozenge containing an antacid, which comprises mixing liquid sucrose, corn syrup, and a carbonate antacid into a mixture, the ratio of sucrose to corn syrup being within the range of 1.22:11:1, heating the mixture to a first temperature of between 105.degree. and 115.degree. C. by a cooking means, transferring the mixture to a second cooking chamber and heating the mixture to a second temperature, exposing said mixture to a vacuum, transferring the mixture to an in-line mixer, mixing the mixture in the in-line mixer and adding a cold-flow enhancer, flavoring, and optionally coloring, and forming the mixture into lozenges.
A process for manufacturing a hard-candy lozenge containing an antacid, which consists essentially of mixing 67% concentrated aqueous liquid sucrose, 80% concentrated aqueous corn syrup, and calcium carbonate into a mixture, heating the mixture to about 110.degree. C. by a cooking means, transferring the mixture to a vacuum-cooking chamber and heating the mixture in the vacuum cooking chamber to about 145.degree. C. under a negative pressure vacuum of 0.8 to 1.2 bar, transferring the mixture to an in-line mixer, mixing the mixture in the in-line mixer and adding about 1.5% propylene glycol or glycerine, 0.14% flavoring, and 0.14% coloring, and forming the mixture into lozenges.
Dependencies are inferred from the claim text.