Method of treating rheumatoid arthritis with type II collagen
AssigneeAutoimmune, Inc.
InventorsDavid E. Trentham, Howard L. Weiner, David A. Hafler
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Abstract
The present invention is directed to a method and pharmaceutical formulations for the treatment of autoimmune arthritis and animal models therefore in mammals, including humans, by the oral, enteral or by-inhalation administration of whole collagen protein or biologically active peptide fragments of collagen.
Claims7
A method for treating rheumatoid arthritis comprising oral administration of whole collagen II protein to a human in need of treatment, in an amount effective and for a period of time sufficient to decrease at least one clinical symptom selected from the group consisting of joint tenderness, joint swelling, morning stiffness, grip strength, and 50-foot walk time.
A method for treating rheumatoid arthritis in a human in need of such treatment comprising oral administration to said human an amount of protein consisting of whole type II collagen, said amount being effective to decrease at least one arthritis symptom.
A method for treating rheumatoid arthritis in a human in need of such treatment comprising oral administration of whole type II collagen in an amount effective to suppress autoimmune response in at least one afflicted joint of said human.
A method for treating rheumatoid arthritis comprising oral administration of whole collagen II protein to a human in need of such treatment, in an amount effective and for a period of time sufficient to substantially stabilize the arthritic condition while discontinuing cytotoxic drug administration.
Dependencies are inferred from the claim text.