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US 5,399,318 AGranted
Blood sampling apparatus containing an anticoagulant composition
AssigneeAmerican Home Products Corporation
InventorsEdward Mancilla, Elizabeth M. Lagwinska
Life of this patent
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Abstract
Disclosed is a blood sampling apparatus containing an anticoagulant composition which allows for the accurate analysis of blood electrolyte concentrations. The claimed apparatus comprises a receptacle, a blood inlet and the disclosed anticoagulant composition which does not unduly bind sodium, potassium or calcium ions from the sampled blood.
Claims19
An apparatus for use in the collection of blood comprising:
- (1) a receptacle means defining a blood receiving space therein for receiving a blood sample;
- (2) a blood inlet means for introducing a blood sample into the blood receiving space;
- and
- (3) an anticoagulant present within said blood receiving space, said anticoagulant having been produced by a process comprising:
- a) contacting an aqueous solution of sodium heparin with an acidic ion exchange resin for a period sufficient such that aqueous effluent produced possesses a pH of about 3 or less;
- b) reacting said effluent with a heavy metal-containing compound suitable to produce a heavy metal heparin salt;
- and
- c) reacting said heavy metal heparin salt with an aqueous solution of lithium salts in sufficient amounts such that the resulting solution exhibits a pH of about 6 to about 7.
5 more elements
An apparatus for use in the collection of blood comprising:
- (1) a receptacle means defining a blood receiving space therein for receiving a blood sample;
- (2) a blood inlet means for introducing a blood sample into the blood receiving space;
- and
- (3) an anticoagulant present within said blood receiving space, said anticoagulant having been produced by a process comprising:
- a) passing an aqueous solution of sodium heparin through a bed of an acidic ion exchange resin to produce an aqueous effluent having a pH of about 3 or less;
- b) reacting said aqueous effluent with zinc acetate dihydrate in amounts ranging from about 2 to about 7 grams per each 15 grams of sodium heparin used in step (a);
- c) reacting the product of step (b) with an aqueous solution of lithium hydroxide sufficient to produce a solution having a pH of about 6 to about 6.5;
- d) optionally, filtering the solution of step (c);
- e) optionally, drying the solution of either step (c) or step (d).
6 more elements
Dependencies are inferred from the claim text.