Method of lysing thrombi
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsCarl G. Lauer, Barbara Alving
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Abstract
This invention relates to the prevention and treatment of thrombi using pminogen activators, including t-PA, urokinases, and streptokinases, in conjunction with intermittent (pulsed mode) ultrasound. A preferred modality interposes liquid-containing interface between the skin of the patient and the transducer of the ultrasound generator.
Claims20
A non-invasive method of lysing thrombi comprising the steps of:
- 1) adminstering a plasminogen activating effective amount of at least one plasminogen activating factor to a patient suffering from thrombosis;
- 2) placing aganist a body surface of said patient which is near said thrombus a liquid-containing structure or a material to form an interface aganist which the contact surface of the transducer of an ultrasound generator is placed;
- and
- 3) adminstering intermittent (pluse mode) ultrasound at a thrombus lysing effective frequency and power such that said frequency and power are acoustic streaming-inducing and non-cavitational.
A non-invasive method of preventing formation of thrombi comprising the steps of:
- 1) administering a plasminogen activating effective amount of at least one plasminogen activating factor to a mammal;
- 2) placing aganist a body surface of said mammal which is near an area likely to develop a thrombus a liquid-containing structure or a material to form an interface aganist which the contact surface of an ultrasound generator transducer is placed;
- and
- 3) administering intermittent (pulse mode) ultrasound at a thrombus lysing effective frequency and power such that said frequency and power are acoustic streaming-inducing and non-cavitational.
A non-invasive method of lysing thrombi comprising the steps of:
- 1) administering a plasminogen activating effective amount of at least one plasminogen activating factor to a patient suffering from thrombosis;
- 2) placing aganist a body surface of said patient which is near said thrombus a contact surface of an ultrasound generator transducer and
- 3) administering intermittent (pulse mode) ultrasound at a thrombus lysing effective frequency and power such that said frequency and power are acoustic streaming-inducing and non-cavitational.
A non-invasive method of preventing formation of thrombi comprising the steps of:
- 1) administering a plasminogen activating effective amount of at least one plasminogen activating factor to a mammal;
- 2) placing aganist surface of mammal which is near said the area likely to develop a thrombus a contact surface of an ultrasound generator transducer;
- and
- 3) administering intermittent (pulse mode) ultrasound at a thrombus lysing effective frequency and power such that said frequency and power are acoustic streaming-inducing and non-cavitational.
Dependencies are inferred from the claim text.