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US 5,397,989 AGranted
Directly coupled sample changer system for fluid NMR spectroscopy
AssigneeBruker Analytische Messtechnik GmbH
InventorsManfred Spraul, Martin Hofmann
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AssigneeBruker Analytische Messtechnik GmbH
InventorsManfred Spraul, Martin Hofmann
Estimating the term…
An NMR spectrometer (10) for the measurement of liquid samples having a probe head (20) exhibiting an upper and a lower support (21 or 22), a connector (5) for a feed conduit (15) for the introduction of a liquid sample (1) into the spectrometer (10) and a connector (6) for a drain conduit (16) for the drainage of the liquid sample (1) out of the spectrometer (10), a sample tube (3), arranged between the upper and the lower supports (21 or 22), for the acceptance of the fluid sample (1), whereby the one end of the sample tube (3) is connected to the connector (5) for the feed conduit (15) and the other end to the connector (6) for the drain conduit (16), exhibits, coaxially to the sample tube (3) a further tube (4) for the acceptance of a calibration fluid (2) which, on one end, is connected to an additional connector (7) for a feed conduit (17) to introduce the calibration fluid (2) into the spectrometer (10) and, on its other end, to an additional connector (8) for a drain conduit (18) to drain the calibration fluid (2) out of the spectrometer (10). In this manner, it is possible to measure the sample fluid (1) in a simple fashion, without the previous mixing of additives and, subsequent to the measurement, to regain the sample fluid in its original state, while allowing for the introduction of a calibration fluid (2) for field stabilization and for the quantitative comparison of line intensities.
A nuclear magnetic resonance (NMR) spectrometer for the measurement of fluid samples, comprising a magnetic system for the production of a homogeneous static magnetic field B.sub.0, a probe head exhibiting an upper and a lower support, a feed conduit connector communicating with a feed conduit for the introduction, of the fluid sample into the spectrometer, a drain conduit connector communicating with a drain conduit to drain the fluid sample out of the spectrometer, a sample tube arranged between the upper and the lower supports for the acceptance of the fluid sample, the sample tube having a first end communicating with the feed conduit connector and a second end communicating with the drain conduit connector, and a radio frequency (RF)-coil surrounding the sample tube for at least one of a production and a detection of an RF-magnetic field directed, in a measurement volume within the sample tube, perpendicular to the direction of the static magnetic field B.sub.o, further comprising an additional tube, coaxial to the sample tube, adapted to accept a calibration fluid, the additional tube having a first end communicating with an additional feed conduit connector for an introduction of a calibration liquid into the spectrometer and a second end communicating with an additional drain conduit connector to drain the calibration fluid out of the spectrometer.
A method for the operation of an NMR spectrometer of the kind having a probe head comprising a sample tube communicating with a feed and a drain conduit and an additional tube communicating with an additional feed and additional drain conduit, the method comprising injecting a calibration fluid into the additional tube and subsequently further comprising the steps of:
Dependencies are inferred from the claim text.