Vasodilatory peptides from the salivary gland of the sand fly Lutzomyia longipalpis
AssigneePresident and Fellows of Harvard College
InventorsJose M. C. Ribeiro, Ethan A. Lerner, Heinz G. Remold, Richard G. Titus
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Abstract
Disclosed are proteins derived from the sand fly Lutzomyia longipalpis capable of inducing vasodilation in mammals, and data characterizing the proteins and nucleic acid encoding the proteins. Also disclosed is a method for temporarily inactivating the immune system in a mammal comprising administering to the mammal the Lutzomyia protein, CGRP, calcitonin, or active immune suppressing analogs thereof.
Claims10
An essentially pure protein obtained from the salivary gland lysate of the sand fly Lutzomyia longipalpis which protein induces vasodilation in a mammal and which is essentially free of all other lysate proteins.
A vasodilatory protein having the amino acid sequence shown in SEQ ID NO. 2.
A vasodilatory protein having the amino acid sequence shown in SEQ ID NO:
- 4.
A composition comprising a therapeutically effective amount a vasodilatory protein obtained from the salivary gland lysate of the sand fly Lutzomyia longipalpis and a pharmaceutically acceptable carrier.
A vasodilatory protein having the amino acid sequence of 18-80 as shown in SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.