Method of treating Infectious Bursal Disease Virus infections

A vaccine preparation useful for producing active immunity against Infectious Bursal Disease in an avian subject, said vaccine preparation comprising:

• a pharmaceutically acceptable formulation consisting essentially of a vaccine complex;
• said vaccine complex further comprising a live Infectious Bursal Disease Virus and a neutralizing factor bound to said live virus;
• said live virus being a pathogenic virus capable of causing disease in said subject;
• said neutralizing factor selected from the group consisting of antibodies and antibody fragments which neutralizing the live virus;
• said vaccine complex included in said pharmaceutically acceptable formulation in an amount effective to produce an active immune response to said live virus in said subject.

An article of manufacture comprising a closed, pathogen-impermeable container and a sterile vaccine preparation enclosed within said container, said vaccine preparation useful for producing active immunity against Infectious Bursal Disease in an avian subject, said vaccine preparation comprising:

• a pharmaceutically acceptable formulation consisting essentially of a vaccine complex;
• said vaccine complex comprising a live Infectious Bursal Disease Virus and a neutralizing factor bound to said live virus;
• said live virus being a pathogenic virus capable of causing disease in said subject;
• said neutralizing factor selected from the group consisting of antibodies and antibody fragments which neutralize said live virus;
• said vaccine complex included in said pharmaceutically acceptable carried in an amount effective to produce an active immune response to said live virus in said subject.

A method of producing active immunity against Infectious Bursal Disease in an avian subject, said method comprising:

• administering to the subject a vaccine complex further comprising live Infectious Bursal Disease Virus and a neutralizing factor bound to the live virus;
• the neutralizing factor selected from the group consisting of antibodies and antibody fragments which neutralize the live virus;
• said live virus being a pathogenic virus capable of causing disease in said subject;
• and wherein the neutralizing factor is of monoclonal origin;
• said vaccine complex administered in an amount effective to produce an active immune response to the live virus in the subject.

A vaccine preparation useful for producing active immunity against Infectious Bursal Disease in an avian subject, said vaccine preparation comprising:

• a pharmaceutically acceptable formulation comprising a vaccine complex;
• said vaccine complex further comprising live Infectious Bursal Disease Virus and a neutralizing factor bound to said live virus;
• said live virus being a pathogenic virus capable of causing disease in said subject;
• said neutralizing factor selected from the group consisting of antibodies and antibody fragments which neutralize the live virus;
• and wherein said neutralizing factor is a monoclonal factor;
• said vaccine complex included in said pharmaceutically acceptable formulation in an amount effective to produce and active immune response to said live virus in said subject.

An article of manufacture comprising a closed, pathogen-impermeable container and a sterile vaccine preparation enclosed within said container, said vaccine preparation useful for producing active immunity against Infectious Bursal Disease in an avian subject, said vaccine preparation comprising:

• a pharmaceutically acceptable formulation comprising a vaccine complex;
• said vaccine complex further comprising live Infectious Bursal Disease Virus and a neutralizing factor bound to said live virus, said live virus being a pathogenic virus capable of causing disease in said subject;
• said neutralizing factor selected from the group consisting of antibodies and antibody fragments which neutralize the live virus;
• and wherein said neutralizing factor is a monoclonal factor;
• said vaccine complex included in said pharmaceutically acceptable carrier in an amount effective to produce an active immune response to said live virus in said subject.