Transdermal dosimeter device

In a device for the transdermal collection of a composition from the physiologic system of a mammal, which comprises;

• a container for holding the composition;
• and adhesive means on the container for adhering the container to a wearer's skin;
• the improvement, which comprises;
• a tamper-indicating label associated with the adhesive means, said label comprising;
• a) a transparent facestock,
• b) a transparent release coating attached to a portion of one surface of the facestock for providing an indicia,
• c) a transparent primer attached to said surface of the facestock and said release coating forming a relatively continuous planar surface on said surface of the facestock,
• d) a relatively planar frangible, visible metal layer attached to said primer layer, and
• e) an adhesive layer attached to said metal layer;
• wherein said indicia is not visible until becoming permanently visible when said facestock is separated from said release coating;
• whereby if the adhesion between the skin and the container is broken, the label will give permanent indication of the breakage.