Hydrazones

A compound of formula I ##STR9## wherein A is a direct bond;

• X is a radical --C(.dbd.Y)--NR.sub.6 R.sub.7 ;
• Y is NR.sub.8 ;
• Z is NR.sub.9 ;
• R.sub.1 and R.sub.2 are each independently of the other hydrogen or one or more substituents selected from the group consisting of lower alkyl, trifluoromethyl, cycloalkyl, aryl-lower alkyl, hydroxy, lower alkoxy, aryl-lower alkoxy, aryloxy, halogen, amino, N-lower alkylamino, N,N-di-lower alkylamino, lower alkanoylamino, nitro, lower alkanoyl, arylcarbonyl, mercapto, lower alkylthio, lower alkylsulfonyl, sulfamoyl, N-lower alkylsulfamoyl and N,N-di-lower alkylsulfamoyl, aryl being phenyl or naphthyl that is unsubstituted or substituted by one or more substituents from the group consisting of lower alkyl, lower alkoxy, hydroxy, nitro, amino, halogen, trifluoromethyl, lower alkanoyl, benzoyl that is unsubstituted or substituted by lower alkyl, lower alkoxy, hydroxy, halogen or by trifluoromethyl, lower alkylsulfonyl, sulfamoyl, N-lower alkylsulfamoyl and N,N-di-lower alkylsulfamoyl;
• the radicals R.sub.3, R.sub.4, R.sub.6, R.sub.8 and R.sub.9 are each independently of the others hydrogen or lower alkyl;
• and R.sub.5 and R.sub.7 are each independently of the other hydrogen, lower alkyl, hydroxy, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, lower alkyleneamino or oxa-, thia- or aza-lower alkyleneamino;
• a tautomer thereof, or a pharmaceutically acceptable salt thereof.