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US 5,395,847 AGranted
Imidazolyl-alkenoic acids
AssigneeSmithKline Beecham Corporation
InventorsJoseph Weinstock, Dimitri E. Gaitanopoulos
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Abstract
Angiotensin II receptor antagonists having tile formula: ##STR1## or a pharmaceutically acceptable salt thereof which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals. These antagonists function as prodrugs in vivo.
Claims11
A compound of the formula:
- ##STR3## wherein:
- R.sup.1 is 4-carboxy-1-naphthalenyl or 4-carboxyphenyl;
- and
- R.sup.2 is C.sub.2-8 alkyl, C.sub.2-8 alkoxy, or C.sub.2-8 alkylthio;
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.