Imidazopyridine derivatives and their use

An angiogenesis inhibitory composition comprising a compound of the formula (1):

• ##STR69## wherein A' is a divalent optionally substituted C.sub.1-15 hydrocarbon group which may contain ethereal oxygen at any possible position;
• R.sup.a and R.sup.b are the same or different and are a hydrogen, an optionally substituted hydrocarbon group, a halogen, a nitro group, a nitroso group, an optionally protected amino group, a lower alkoxycarbonyl group or a lower alkyl carbamoyl group;
• R.sup.c is a hydrogen or an optionally substitued hydrocarbon group or may form a ring together with the carbon atom of A';
• and R.sup.d is an optionally substituted hydrocarbon group, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient.