6-substituted quinazolines processing anti-tumor activity

A quinazoline of the formula I

• wherein
• R.sup.1 is hydrogen or amino, or alkyl or alkoxy each of up to 6 carbon atoms;
• or R.sup.1 is alkyl of up to 3 carbon atoms which bears a hydroxy substituent, or which bears one, two or three fluoro substituents;
• or R.sup.1 is hydroxyalkoxy of up to 3 carbon atoms or alkoxyalkoxy of up to 6 carbon atoms;
• wherein the quinazoline ring may bear no further substituents or may bear one further substituent selected from halogeno and from alkyl and alkoxy each of up to 3 carbon atoms;
• wherein R.sup.2 is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, halogenoalkyl or cyanoalkyl each of up to 6 carbon atoms;
• wherein Ar is phenylene, thienylene or pyridylene which may be unsubstituted or may bear one or two substituents selected from halogeno, hydroxy, amino and nitro, and from alkyl, alkoxy and halogenoalkyl each of up to 3 carbon atoms;
• wherein L is a group of the formula --CO.NH--, --CO.NR.sup.3 -- or --CO.O--, wherein R.sup.3 is alkyl of up to 6 carbon atoms;
• and wherein Y is heteroaryl or a hydrogenated derivative thereof;
• or
• Y is a group of the formula --A--Y.sup.1 in which A is alkylene of up to 6 carbon atoms, and Y.sup.1 is heteroaryl or a hydrogenated derivative thereof;
• wherein one constituent methylene group in A may be replaced by an oxy, thio, sulphinyl, sulphonyl or imino group or an alkylimino group of up to 6 carbon atoms;
• and
• wherein each of said heteroaryl groups, or hydrogenated derivatives thereof, may be unsubstituted or may bear up to three substituents selected
• i) from hydroxy, oxo, amino, nitro, cyano, carbamoyl, sulphamoyl, carboxy and halogeno,
• ii) from alkyl, alkylamino, dialkylamino, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, alkoxycarbonyl, alkanoyloxyalkyl, alkylthio, alkylsulphinyl, alkysulphonyl, alkoxy, halogenoalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, carboxyalkyl, alkoxycarbonylalkyl, carbamoylalkyl, N-alkylcarbamoylalkyl and N,N-dialkylcarbamoylalkyl each of up to 6 carbon atoms, and
• iii) from phenyl, pyridyl and phenylalkyl of up to 10 carbon atoms, and wherein each of said phenyl or phenylalkyl groups may bear a substituent selected from halogeno and nitro, and from alkyl and alkoxy each of up to 3 carbon atoms;
• or a pharmaceutically-acceptable salt thereof;
• provided that when R.sup.1 is hydrogen or amino, or alkyl of up to 6 carbon atoms, and L is a group of the formula --CONH--, then Y is not tetrazolyl.