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US 5,395,835 AGranted
Naphthalamides as central nervous system agents
AssigneeWarner-Lambert Company
InventorsShelly A. Glase, Suzanne R. Kesten, Lawrence D. Wise, Jonathan Wright
Life of this patent
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Abstract
Naphthalamides are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as antipsychotic agents and as agents for the treatment of disorders which respond to dopaminergic blockade including psychotic depression, substance abuse, and compulsive disorders.
Claims6
A compound of Formula I ##STR10## wherein R and R.sup.1 are the same or different and each is hydrogen,
- alkyl of from one to six carbon atoms,
- alkoxy of from one to six carbon atoms,
- thioalkoxy of from one to six carbon atoms,
- hydroxy,
- amino,
- alkylamino wherein alkyl is from one to six carbon atoms,
- or
- dialkylamino wherein alkyl is from one to six carbon atoms;
- R.sup.2 is halogen,
- nitro,
- cyano,
- SO.sub.2 NH--,
- alkyl of from one to six carbon atoms, or
- alkoxy of from one to six carbon atoms;
- R.sup.3 is hydrogen,
- hydroxy, or
- methoxy;
- R.sup.4 is hydrogen or
- alkyl of from one to six carbon atoms;
- and
- R.sup.5 is
- phenyl,
- phenyl substituted by one to three substituents selected from the group consisting of halogen, hydroxy, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms, thioalkoxy of from one to six carbon atoms or cyano,
- -- .
21 more elements
Dependencies are inferred from the claim text.