Loading patent…
AssigneeHokuriku Seiyaku Co., Ltd.
InventorsYasuo Ito, Hideo Kato, Shingo Yasuda, Nobuhiko Iwasaki, Hiroyuki Nishino, Makoto Takeshita
Estimating the term…
A benzamide derivative represented by the following formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkanoyl group; R.sup.2 represents a hydrogen atom or a halogen atom; R.sup.3 represents a lower alkoxy group; R.sup.4 represents a hydrogen atom or a lower alkyl group; R.sup.5 represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; A represents C.sub.1 -C.sub.7 alkylene group which may optionally be substituted with a lower alkyl group; X represents a methylene group, an oxygen atom, or a sulfur atom; m represents an integer of from 0 to 3; n represents an integer of from 0 to 3; and p represents an integer of from 0 to 2 and a pharmacologically acceptable salt thereof is provided. These compounds are useful since they have gastrointestinal stimulating activity, and a pharmaceutical composition comprising said compound is useful for the treatment of gastrointestinal diseases.
A benzamide derivative represented by the following formula:
Ethyl endo-[3-(4-amino-5-chloro-2-methoxybenzamido)-9-azabicyclo[3.3.1]non-9-yl] acetate and a pharmacologically acceptable salt thereof.
Endo-[3-(4-amino-5-chloro-2-methoxybenzamido)-9-azabicyclo[ 3.3.1]non-9-yl]acetic acid and a pharmacologically acceptable salt thereof.
Ethyl endo-4-[3-(4-amino-5-chloro-2-methoxybenzamido)-9-azabicyclo[3.3.1]non-9-y l]butyrate and a pharmacologically acceptable salt thereof.
Endo-4-[3-(4-amino-5-chloro-2-methoxybenzamido)-9-azabic yclo[3.3.1]non-9-yl ]butyric acid and a pharmacologically acceptable salt thereof.
Ethyl endo-[3-(4-amino-5-chloro-2-methoxybenzamido)-8-azabicyclo[3.2.1]oct-8-yl] acetate and a pharmacologically acceptable salt thereof.
Endo-[3-(4-amino-5-chloro-2-methoxybenzamido)-8-azabi cyclo[3.2.1]oct-8-yl]acetic acid and a pharmacologically acceptable salt thereof.
Ethyl endo-4-[3-(4-amino-5-chloro-2-methoxybenzamido)-8-azabicyclo[3.2.1]oct-8-y l]butyrate and a pharmacologically acceptable salt thereof.
Endo-4-[3-(4-amino-5-chloro-2-methoxybenzamido)-8-azabic yclo[3.2.1]oct-8-yl ]butyric acid and a pharmacologically acceptable salt thereof.
A pharmaceutical composition comprising a benzamide derivative represented by the following formula:
A method for treatment of gastrointestinal diseases comprising the step of administering to a patient an effective amount of a benzamide derivative represented by the following formula:
Dependencies are inferred from the claim text.