Treating cardiac disorders with .DELTA.9(11)-dehydro-8-isoestrone
AssigneeAmerican Home Products Corporation
InventorsFrederick O. Gemmill, Jr., Chester E. Orzech, Steven J. Adelman
Life of this patent
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Abstract
This invention relates to 8.alpha.-3-hydroxyestra- 1,3,5( 10),9( 11 )tetraen-17-one (.DELTA.9( 11 )-dehydro-8-isoestrone) (VI), ##STR1## to the process for its preparation, to pharmaceutical compositions containing said 8.alpha.-3-hydroxyestra- 1,3,5(10), 9(11)tetraen-17-one (.DELTA.9(11)-dehydro-8-isoestrone) (VI) and to the use of said 8.alpha.-3-hydroxyestra-1,3,5(10),9(11 )tetraen-17-one (A9( 11 )-dehydro-8-isoestrone) (VI) for modifying the balance between bone production and bone resorption, and as an antioxidant in a host animal, including man.
Claims2
A method of treating atherosclerosis in a mammal which comprises administering an effective amount of .DELTA.9(11)-dehydro-8-isoestrone to said mammal.
A method of treating coronary artery disease in a mammal which comprises administering an effective amount of a .DELTA.9(11)-dehydro-8-isoestrone to said mammal.
Dependencies are inferred from the claim text.