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US 5,395,823 AGranted
Neuropeptide Y agonists and partial agonists
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorJohn L. Krstenansky
Life of this patent
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Abstract
Agonists of NPY which are derivatives of naturally occurring NPY. The agonism is confirmed using conventional competitive binding and biochemical assays and the use of these derivatives in a variety of conditions in which neuropeptide Y is implicated is also described.
Claims9
A peptide derivative of the formulae ##STR12## wherein X.sub.1 is E;
- X.sub.2 is S or A;
- X.sub.3 is S or A;
- X.sub.4 is L, or I;
- X.sub.5 is L, or I;
- X.sub.6 is Q, P, or H;
- Tc is OR' or NHR';
- wherein R' is a hydrogen or a (C.sub.1 -C.sub.4)alkyl group;
- .theta. is a group of the structural formula
- --NH--(CH.sub.2).sub.n --CO.sub.2 --;
- wherein n is an integer of from 1-11 or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.