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US 5,395,688 AGranted
Magnetically responsive fluorescent polymer particles
AssigneeBaxter Diagnostics Inc.
InventorsChao-Huei J. Wang, Dinesh Q. Shah
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AssigneeBaxter Diagnostics Inc.
InventorsChao-Huei J. Wang, Dinesh Q. Shah
Estimating the term…
This invention provides a novel process of producing magnetically responsive fluorescent polymer particles comprising polymeric core particles coated evenly with a layer of polymer containing magnetically responsive metal oxide. A wide variety of polymeric particles with sizes ranging from 1 to 100 microns can be used a core particles and transformed into magnetically responsive polymer particles. The surface of these magnetically responsive polymer particles can be coated further with another layer of functionalized polymer. These magnetically responsive fluorescent polymer particles can be used for passive or covalent coupling of biological material such as antigens, antibodies, enzymes or DNA/RNA hybridization and used as solid phase for various types of immunoassays, DNA/RNA hybridization probes assays, affinity purification, cell separation and other medical, diagnostic, and industrial applications.
Monodispersed fluorescent magnetic particles having an average diameter from about 1 micron to about 100 microns, a uniform size distribution and magnetic content, comprising an inner fluorescent core polymer particle able to adsorb a monomer, and a coating on said inner fluorescent core polymer particle wherein said coating evenly covers said inner fluorescent core polymer particle, said coating comprising magnetic metal oxide particles of about 1 micron or less in diameter and selected from the group consisting of supermagnetic, paramagnetic and ferromagnetic metal oxide particles and a polymer, wherein said polymer is prepared from monomers which are adsorbable by the inner fluorescent core polymer particle.
Monodispersed fluorescent magnetic particles having an average diameter from about 1 to 100 microns, a uniform size distribution and magnetic content, comprising an inner core polymer particle able to adsorb a monomer, and a coating on the inner core polymer particle wherein the coating evenly covers the inner core polymer particles, said coating comprising a fluorescent dye or combination of fluorescent dyes, magnetic metal oxide particles of about 1 micron or less in diameter and selected from the group consisting of paramagnetic, supermagnetic and ferromagnetic metal oxides and a polymer, said polymer being prepared from monomers which are adsorbable by the inner core polymer particle.
Dependencies are inferred from the claim text.