Controlled release succinic acid microcapsules coated with aqueous acrylics
AssigneeTanabe Seiyaku Co., Ltd.
InventorsKazuo Noda, Yoshiyuki Hirakawa, Hiroyuki Yoshino, Shinji Narisawa
Life of this patent
Estimating the term…
Abstract
A controlled release pharmaceutical preparation comprising (a) a core containing a pharmaceutically active substance and an organic acid, and (b) a coating film formed on the surface of the core by aqueous coating of a water-insoluble and water-slightly permeable acrylic polymer containing a trimethylammonium-ethyl group, which exhibits well controlled dissolution and release of the pharmaceutically active substance when administered and can maintain the desired blood level of the active substance for a long period of time, and a method for producing the preparation.
Claims12
A controlled release pharmaceutical preparation which comprises (a) a core containing an orally acceptable pharmaceutically active substance and succinic acid, and (b) a coating film formed on the surface of the core by coating with an aqueous dispersion of a water-insoluble and water-slightly permeable acrylic copolymer of ethyl acrylate, methyl methacrylate and trimethylammonium-ethyl methacrylate chloride.
A method for producing a controlled release pharmaceutical preparation, which comprises coating a core containing an orally acceptable pharmaceutically active substance and succinic acid with an aqueous dispersion of a water-insoluble and water-slightly permeable acrylic copolymer of ethyl acrylate, methyl methacrylate and trimethylammonium-ethyl methacrylate chloride.
Dependencies are inferred from the claim text.