Phenolic amine depigmenting and antimelanoma agents
AssigneeThe Governors of the University of Alberta
InventorKowichi Jimbow
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Abstract
A composition useful for treating skin pigmentation, melasma and melanoma comprises: i) a biologically effective amount of derivatives of 4-S-cysteaminylphenyl such as N-acetyl-4-S-cysteaminylphenol, .alpha.-methyl-4-S-cysteaminylphenol, N,N'-dimethyl-4-S-cysteaminylphenol and 4-S-homocysteaminylphenol; and ii) a suitable biologically compatible carrier for the selected active compound.
Claims38
A composition for use in blocking melanin synthesis in human or animal melanocyte cells comprising:
- (i) a melanin synthesis-blocking amount of an active compound selected from the group of compounds represented by the formula (I):
- ##STR6## wherein R.sub.1 is H or C.sub.1 to C.sub.8 alkyl;
- R.sub.2 is H;
- R.sub.3 is H, C.sub.1 to C.sub.8 alkyl or C.sub.1 to C.sub.8 alkanoyl, and
- x is 1 to 5
- with the proviso that R.sub.1 or R.sub.3 is other than H;
- and
- (ii) a suitable biologically compatible carrier for the selected active compound.
A composition for use in treating hyperpigmentation comprising:
- (i) a depigmenting effective amount of an active compound selected from the group of compounds represented by the formula (I):
- ##STR7## wherein R.sub.1 is H or C.sub.1 to C.sub.8 alkyl;
- R.sub.2 is H;
- R.sub.3 is H or C.sub.1 to C.sub.8 alkyl or C.sub.1 to C.sub.8 alkanoyl, and
- x is 1 to 5
- with the proviso that R.sub.1 or R.sub.3 is other than H;
- and
- (ii) a suitable biologically compatible carrier for the selected active compound.
A composition for use in treating melanoma comprising:
- (i) an anti-melanoma effective amount of an active compound selected from the group of compounds represented by the formula (I):
- ##STR8## wherein R.sub.1 is H or C.sub.1 to C.sub.8 alkyl;
- R.sub.2 is H;
- R.sub.3 is H or C.sub.1 to C.sub.8 alkyl or C.sub.1 to C.sub.8 alkanoyl, and
- x is 1 to 5
- with the proviso that R.sub.1 or R.sub.3 is other than H;
- and
- (ii) a suitable biologically compatible carrier for the selected active compound.
A topical pharmaceutical composition comprising:
- (i) an active compound selected from the group of compounds represented by the formula (I):
- ##STR9## wherein R.sub.1 is H or C.sub.1 to C.sub.8 alkyl;
- R.sub.2 is H;
- R.sub.3 is H, C.sub.1 to C.sub.8 alkyl or C.sub.1 to C.sub.8 alkanoyl, and
- x is 1 to 5
- with the proviso that R.sub.1 or R.sub.3 is other than H;
- and
- (ii) a pharmaceutically acceptable topical carrier for the selected active compound.
Dependencies are inferred from the claim text.