Method of construction of a mass transfer device

A method of making a hollow fiber separation device comprising the sequential steps of:

• winding at least one hollow fiber around a supporting core, said supporting core defining a longitudinal axis extending therethrough, then
• mounting an outer casing adjacent the exterior of said hollow fibers, then
• cutting said hollow fibers in at least two circumferentially spaced locations to form a fiber bundle having a first cut end at which the interiors of a first end of said hollow fibers are exposed and a second cut end at which the interiors of a second end of said hollow fibers are exposed, then
• sealing between the first cut ends of said hollow fibers in said fiber bundle,
• sealing between the second cut ends of said hollow fibers in said fiber bundle, such that the seal between the first and second cut ends of said fiber bundle and said core section and said casing section together define a molecular transfer chamber, then
• coupling first fluid inlets to the interior of said hollow fibers at the first cut ends of said hollow fibers in said fiber bundle and coupling first fluid outlets to the interior of said hollow fibers at the second cut ends of said hollow fibers in said fiber bundle,
• coupling second fluid inlets to said molecular transfer chamber for allowing said second fluid to enter said molecular transfer chamber and coupling second fluid outlets to said molecular transfer chamber for allowing said second fluid to exit from said molecular transfer chamber.

A method of making hollow fiber bundles for use in oxygenators, the oxygenators having an outer casing and a core section between which is an oxygenation chamber which houses the fiber bundle, a gas inlet operatively coupled to the interior of the hollow fibers at a first end of the fiber bundle and a gas outlet operatively coupled to the interior of the hollow fibers at a second end of the fiber bundle which is spacially separated from the first end of the fiber bundle, a blood inlet and a blood outlet operatively coupled to the oxygenation chamber for allowing blood to enter and exit from the oxygenation chamber, the method comprising:

• the sequential steps of
• winding one or more hollow gas permeable fibers around a support core, said support core including a first core section and a second core section and defining a longitudinal axis, then
• mounting a first outer casing and a second outer casing adjacent to said hollow gas permeable fibers such that said hollow gas permeable fibers are between said first and second outer casings and said support core, then
• cutting said through said hollow gas permeable fibers in at least two circumferentially spaced locations such that said fibers are divided into a first hollow fiber bundle lying generally between said first outer casing and said first core section and a second hollow fiber bundle lying generally between said second outer casing and said second core section, whereby said first and second fiber bundles may be used in separated oxygenators.

A method of making an oxygenator comprising the sequential steps of:

• winding at least one gas permeable hollow fiber around a supporting core, said supporting core having a longitudinal axis, then
• mounting an outer casing around the exterior of said hollow fibers, then
• cutting said hollow fibers in at least two circumferentially spaced locations to form a fiber bundle having a first cut end at which the interiors of a first end of said hollow fibers are exposed and a second cut end at which the interiors of a second end of said hollow fibers are exposed, then
• sealing between the first cut ends of said hollow fibers in said fiber bundle,
• sealing between the second cut ends of said hollow fibers in said fiber bundle, such that the seal between the first and second ends of said fiber bundle and said core section and said casing section together define an oxygenation chamber, then
• coupling gas inlets to the interior of said hollow fibers at the first cut ends of said hollow fibers in said fiber bundle and coupling gas outlets to the interior of said hollow fibers at the second ends of said hollow fibers in said fiber bundle,
• coupling blood inlets to said oxygenation chamber for allowing blood to enter said oxygenation chamber and coupling blood outlets to said oxygenation chamber for allowing blood to exit from said oxygenation chamber.

A method of making an oxygenator comprising the sequential steps of:

• winding at least one gas permeable hollow fiber around a supporting core, said supporting core including first and second core sections and defining a longitudinal axis, then
• mounting an outer casing around the exterior of said hollow fibers, said outer casing having a first casing section and a second casing section, then
• cutting through said hollow fibers in at least two circumferentially spaced locations such that said fibers are divided into a plurality of fiber bundles including first and second fiber bundles, said first and second fiber bundles each having a first cut end at which the interiors of a first end of said hollow fibers are exposed and a second cut end at which the interiors of a second end of said hollow fibers are exposed, said first fiber bundle lying generally between said first casing section and said first core section and said second fiber bundle lying generally between said second casing section and said second core section, said first fiber bundle, said first core section and said first casing section together forming a first oxygenator, said second fiber bundle, said second core section and said second casing section together forming a second oxygenator, then
• sealing between the first ends of said hollow fibers in said first and second fiber bundles,
• sealing between the second ends of said hollow fibers in said first and second fiber bundles, the sealed areas at the cut ends of said hollow fibers in said first fiber bundle, said first core section and said first casing section together defining a first oxygenation chamber in said first oxygenator, the sealed areas at the cut ends of said hollow fibers in said second fiber bundle, said second core section and said second casing together defining a second oxygenation chamber in said second oxygenator, then
• coupling gas inlets to the interior of said hollow fibers at the first cut ends of said hollow fibers in said first and second hollow fiber bundles and coupling gas outlets to the interior of said hollow fibers at the second cut ends of said hollow fibers in said first and second fiber bundles,
• coupling blood inlets to said first and second oxygenation chambers for allowing blood to enter said oxygenation chambers and coupling blood outlets to said oxygenation chambers for allowing blood to exit from said oxygenation chambers.