Steroid intermediates for the formation of vitamin D.sub.3 analogues
AssigneeHoffmann-La Roche Inc.
InventorsThomas I. Doran, John A. McLane, Masami Okabe, Michelangelo Scalone, Milan R. Uskokovic
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Abstract
The invention comprises compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or acyl; provided that only one of R.sup.1 or R.sup.2 is hydrogen, useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases. The invention also includes a process for making these compounds and steroid intermediates of the process.
Claims10
A compound of the formula ##STR10## wherein R.sup.4, R.sup.5 and R.sup.6 are independently C.sub.1 -C.sub.6 alkyl or phenyl.
A compound of the formula ##STR11## wherein R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are independently C.sub.1 -C.sub.6 alkyl or phenyl.
A compound of the formula ##STR12## wherein R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are independently C.sub.1 -C.sub.6 alkyl or phenyl and X is ##STR13## wherein R.sup.10 is ##STR14## --NHPh,--OPh, --N(CH.sub.3).sub.2, or --SCH.sub.3, and Ph is phenyl.
A compound of the formula ##STR15## wherein R.sup.11 and R.sup.12 are independently ##STR16## hydrogen or acyl, R.sup.4, R.sup.5 and R.sup.6 are independently C.sub.1 -C.sub.6 alkyl or phenyl.
Dependencies are inferred from the claim text.