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US 5,393,896 AGranted
Process for obtaining 10-deacetylbaccatin III
AssigneeRhone-Poulenc Rorer S.A.
InventorRodolphe Margraff
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Abstract
This invention relates to a process for obtaining 10-deacetylbaccatin III from various parts of yew (Taxus sp.) by extraction with a suitable organic solvent of the aqueous solution obtained after treating the appropriate part of yew with water, followed by selective crystallization of 10-deacetylbaccatin III.
Claims32
A process for obtaining 10-deacetylbaccatin III from various parts of yew (Taxus sp.) comprising:
- 1) treating ground parts of yew with water to obtain an aqueous suspension,
- 2) separating an aqueous solution containing 10-deacetylbaccatin III from vegetable matter in the aqueous suspension,
- 3) extracting 10-deacetylbaccatin III from the aqueous solution with an organic solvent,
- 4) separating an organic extract containing 10-deacetylbaccatin III from the aqueous phase,
- 5) removing the organic solvent from the organic extract thus separated to obtain a residue,
- 6) selectively crystallizing 10-deacetylbaccatin III from the residue thus obtained in an organic solvent,
- 7) isolating 10-deacetylbaccatin III in purified form.
4 more elements
Dependencies are inferred from the claim text.