Piperidine derivatives and hypotensives containing the same

A piperidine compound of the formula ##STR4## wherein:

• R is --H, --Cl or --OCH.sub.3 ;
• X is --(CH.sub.2).sub.n --, --CO--(CH.sub.2).sub.4, --CONH--(CH.sub.2).sub.2, --NHCO--(CH.sub.2).sub.2, or --CH.dbd.CH--(CH.sub.2).sub.2 --;
• and
• n is an integer of from 3 to 5;
• Y is --CH.dbd.CH--, --(CH.sub.2).sub.2 --, --OCH.sub.2 --, --SCH.sub.2 --;
• and
• Q is --CN, substituted or unsubstituted piperidinyl, substituted or unsubstituted piperazinyl, substituted or unsubstituted thienyl, substituted or unsubstituted morpholinyl, or substituted or unsubstituted thiomorpholinyl, wherein when Q is substituted, the substituent(s) is/are selected from the group consisting of H--CH.sub.2).sub.3 wherein n is an integer of 1 to 10, Cl--CH.sub.2).sub.3, allyl, formyl, phenyl, isopropyl, hydroxy, methoxy, ethoxy, fluoro, chloro, acetoxy, 2-methoxyacetoxy, carboxyl, methoxycarbonyl, ethoxycarbonyl, cyano, imidazolylmethyl, trifluoromethyl, benzoyl, 2-hdyroxybenzyl, nitro, amino, acetylamino, propanoylamino, butanoylamino, pivaloylamino, trifluoromethylamino, methoxycarbonylamino, ethoxycarbonylamino, cinnamoylamino, methanesulfonylamino, N,N-bis(methanesulfonyl)amino, aminocarbonyl, aminosulfonyl, hydroxymethyl and acetoxymethyl, and wherein when X and/or Q contain --CH.sub.2 -- groups, one or more of the --CH.sub.2 -- groups in X and/or Q may be substituted by --CH.sub.2).sub.4 or --CH.sub.2).sub.5, thereby forming a ring structure.

A piperidine compound of the formula ##STR5## wherein:

• R is --H, --Cl or --OCH.sub.3 ;
• X is --CO--(CH.sub.2).sub.3, --CONH--(CH.sub.2).sub.2, --NHCO--(CH.sub.2).sub.2, or --CH.dbd.CH-- (CH.sub.2).sub.2 --;
• and
• Q is --CN, substituted or unsubstituted cyclohexyl, substituted or unsubstituted piperidinyl, substituted or unsubstituted piperazinyl, substituted or unsubstituted phenyl, substituted or unsubstituted furyl, substituted or unsubstituted thienyl, substituted or unsubstituted pyrrolyl, substituted or unsubstituted pyridyl, substituted or unsubstituted morpholinyl, or substituted or unsubstituted thiomorpholinyl, wherein when Q is substituted, the substituent(s) is/are selected from the group consisting of H--CH.sub.2).sub.n wherein n is an integer of 1 to 10, Cl--CH.sub.2).sub.3, allyl, phenyl, isopropyl, hydroxy, methoxy, ethoxy, fluoro, chloro, acetoxy, 2-methoxyacetoxy, ethoxycarboxyl, carboxyl, methoxycarbonyl, ethoxycarbonyl, cyano, imidazolylmethyl, trifluoromethyl, benzoyl, 2-hydroxybenzyl, nitro, amino, acetylamino, propanoylamino, butanoylamino, pivaloylamino, trifluoromethylamino, methoxycarbonylamino, ethoxycarbonylamino, cinnamoylamino, methanesulfonylamino, N,N-bis(methanesulfonyl)amino, aminocarbonyl, aminosulfonyl, hydroxymethyl and acetoxymethyl, and wherein when X and/or Q contain --CH.sub.2 -- groups, one or more of the --CH.sub.2 -- groups in X and/or Q may be substituted by --CH.sub.2).sub.4 or --CH.sub.2).sub.5 thereby forming a ring structure.

A piperidine compound of the formula ##STR6## wherein:

• R is --H, --Cl or --OCH.sub.3 ;
• X is --(CH.sub.2).sub.n --;
• n is an integer of from 3 to 5;
• and
• Q is --CN, substituted or unsubstituted phenyl, substituted or unsubstituted furyl, substituted or unsubstituted thienyl, substituted or unsubstituted pyrrolyl, substituted or unsubstituted pyridyl, wherein when Q is substituted, the substituent(s) is/are selected from the group consisting of H--CH.sub.2).sub.n wherein n is an integer of 1 to 10, Cl--CH.sub.2).sub.3, allyl, phenyl, isopropyl, hydroxy, methoxy, ethoxy, fluoro, chloro, acetoxy, 2-methoxyacetoxy, ethoxycarboxyl, carboxyl, methoxycarbonyl, ethoxycarbonyl, cyano, imidazolylmethyl, trifluoromethyl, benzoyl, 2-hydroxybenzyl, nitro, amino, acetylamino, propanoylamino, butanoylamino, pivaloylamino, trifluoromethylamino, methoxycarbonylamino, ethoxycarbonylamino, cinnamoylamino, methanesulfonylamino, N,N-bis(methanesulfonyl)amino, aminocarbonyl, aminosulfonyl, hydroxymethyl and acetoxymethyl, and wherein one or more of the --CH.sub.2 -- groups in X may be substituted by --CH.sub.2).sub.4 or --CH.sub.2).sub.5 thereby forming a ring structure.