Antiviral combinations and compounds therefor
AssigneeBurroughs Wellcome Co.
InventorsTodd A. Blumenhopf, Thomas Spector, Devron R. Averett, Robert W. Morrison, Jr., Eric C. Bigham, Virgil L. Styles
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel ribonucleotide reductase inhibitors and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus infections, especially viruses of the herpes group.
Claims6
A compound selected from the group consisting of
- (a) 2-Acetylpyridine 5-((4-Chloroanilino)Thiocarbonyl) Thiocarbonohydrazone;
- (b) 2-Acetylpyridine 5-((2-Methoxy-5-Nitroanilino) Thiocarbonyl)Thiocarbonohydrazone;
- (c) 2-Formylpyridine 5-((2-Chloroanilino)Thiocarbonohydrazone;
- (d) 2-(3-Methylbutyryl)Pyridine 5-((2-Chloroanilino)Thiocarbonyl)Thiocarbonohydrazone;
- (e) 2-Acetylpyridine 5-((3-Chloroanilino)Thiocarbonyl)Thiocarbonohydrazone;
- (f) 2-Acetylpyridine 5-((2-Iodoanilino)Thiocarbonyl)Thiocarbonohydrazone;
- (g) 2-Acetylpyridine 5-((4- (Trifluromethyl)Anilino) Thiocarbonyl)Thiocarbonohydrazone;
- (h) 2-Acetylpyridine 5-((2,3-Dichloroanilino)Thiocarbonyl)Thiocarbonohydrazone;
- (i) 2-Acetylpyridine 5-((3-Iodoanilino)Thiocarbonyl)Thiocarbonohydrazone;
- (j) 2-Acetylpyridine 5-((4-Chloro-2-Methylanilino)Thiocarbonyl)Thiocarbonohydrazone;
- (k) 2-Acetylpyridine 5-((4-Bromoanilino)Thiocarbonyl)Thiocarbonohydrazone
- (l) 2-Acetylpyridine 5-((5-Chloro-2-Methoxyanilino)Thiocarbonyl)Thiocarbonohydrazone;
- (m) 2-Acetylpyridine 5-((2,5-Dichloroanilino)Thiocarbonyl)Thiocarbonohydrazone;
- (n) 2-Acetylpyridine 5-((4-Chloro-3-Nitroanilino)Thiocarbonyl)Thiocarbonohydrazone;
- and
- (o) 2-Acetylpyridine 5-((2,4,5-Trichloroanilino)Thiocarbonyl)Thiocarbonohydrazone.
A compound selected from the group consisting of:
- (a) 2-acetylpyridine 5-(((morpholinoethyl)amino) thiocarbonyl)thiocarbonohydrazone,
- (b) 2-acetylpyridine 5-((2-chloroanilino)thiocarbonyl) thiocarbonohydrazone 1-oxide,
- (c) 3-(1-(((1(2-pyridyl)ethylidene(hydrazino)thiocarbonyl)-4-thiosemicarbazido )benzonitrile,
- (d) 3-(1-(((1-(2-pyridyl)ethylidene(hydrazino)thiocarbonyl)-thiosemicarbazido) benzoic
- (e) 2-acetylpyridine 5-((1-adamantanylamino) thiocarbonyl)thiocarbonohydrazone,
- (f) 2-acetylpyridine 5-(((2-(2-pyridyl)ethyl)amino) thiocarbonyl) thiocarbonohydrazone,
- (g) 2-acetylpyridine 5-((4-methoxyanilino) thiocarbonyl) thiocarbonohydrazone,
- (h) 2-acetylpyridine 5-((2-chlorophenyl)carbamoyl) thiocarbonohydrazone, and
- (i) 2-acetylpyridine (5-(2-chloroanilino)-1,3,4-thiadiazol-2-yl)hydrazone.
The compound 2-acetylpyridine-5-[(2-pyridylamino)thiocarbonyl]thiocarbonohydrazone.
A pharmaceutically acceptable salt of 2-acetylpyridine 5-[(2-pyridylamino)thiocarbonyl]thiocarbonohydrazone.
Dependencies are inferred from the claim text.