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US 5,393,880 AGranted
Cyclodextrin refining process
AssigneeAmerican Maize-Products Company
InventorsWen Shieh, Timothy Dailey, Allan Hedges
Life of this patent
Estimating the term…
Abstract
Cyclodextrin is refined by performing a crystallization step in the presence of a hydrogen bond inhibitor. The hydrogen bond inhibitor includes a base in an amount to adjust the pH of the solution to 8 and above or a non-base such as urea, guanidium hydrochloride and sodium lauryl sulfate in an amount of 0.1% to 2%.
Claims17
A process for refining cyclodextrin comprising the steps of:
- (a) crystallizing a cyclodextrin from an aqueous solution containing unrefined cyclodextrin and having a solids concentration of about 10 to about 40% by weight, said unrefined cyclodextrin obtained from a raw digest which resulted from a treatment of a starch or starch hydrolysate having a DE of 10 and below with a CGTase, said unrefined cyclodextrin comprising at least about 50% by weight cyclodextrin and a remainder of non-cyclodextrin materials, said non-cyclodextrin materials being primarily linear saccharides, in the presence of an effective amount of a hydrogen bond inhibitor, the amount of hydrogen bond inhibitor being effective to prohibit precipitation of the non-cyclodextrin materials during crystallization of the cyclodextrin;
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- (b) recovering the crystallized cyclodextrin which, when added to water, provides a substantially haze free solution.
A process for refining cyclodextrin comprising the steps of:
- (a) crystallizing cyclodextrin from an aqueous solution containing unrefined cyclodextrin and having a solids concentration of about 10 to about 40% by weight, said unrefined cyclodextrin obtained from a raw digest which resulted from a treatment of a starch or starch hydrolysate having a DE of 10 and below with a CGTase, said unrefined cyclodextrin comprising at least about 50% by weight cyclodextrin and a remainder of non-cyclodextrin materials, said non-cyclodextrin materials being primarily linear saccharides, wherein the solution has a pH of about 8 and above;
- and
- (b) recovering the crystallized cyclodextrin which, when added to water, provides a substantially haze free solution.
A process for refining cyclodextrin comprising the steps of:
- (a) adding a sufficient amount of a base to an aqueous solution containing unrefined cyclodextrin and having a solids concentration of about 10 to about 40% by weight, said unrefined cyclodextrin obtained from a raw digest which resulted from a treatment of a starch or starch hydrolysate having a DE of 10 and below with a CGTase, said unrefined cyclodextrin comprising at least about 50% by weight cyclodextrin and a remainder of non-cyclodextrin materials, said non-cyclodextrin materials being primarily linear saccharides, so that the solution has a pH of about 9 to about 12;
- (b) cooling said solution such that crystals of the cyclodextrin start to form;
- and
- (c) recovering the crystallized cyclodextrin which when added to water, provides a substantially haze free solution.
1 more element
Dependencies are inferred from the claim text.