Amino acid derivatives having renin inhibiting activity

Compounds of the formula:

• ##STR14## wherein R.sup.1 is cycloalkyl, phenyl, substituted phenyl, naphthyl, thienyl, pyridyl, ,quinolyl, isoquinolyl or benzyl, R.sup.2 is hydrogen or methyl, R.sup.3 is hydrogen, hydroxy, alkyl, alkoxy, alkenyloxy, alkylthio, alkylthioalkyl or alkoxycarbonyl, or imidazol-1-ylmethyl, imidazol-2-ylmethyl or imidazol-4-ylmethyl, each of which can be methylated on a carbon atom and/or nitrogen atom, 2-aminoimidazol-4-ylmethyl, 5-iodoimidazol-4-ylmethyl, pyrazol-1-ylmethyl, pyrazol-3-ylmethyl, thiazol-2-ylmethyl, thiazol-4-ylmethyl, thiazol-5-ylmethyl, 2-aminothiazol-4-ylmethyl, thienylmethyl, furanylmethyl, pyridylmethyl, aminocarbonyl, aminocarbonylalkyl or alkoxycarbonylalkyl, R.sup.4 is cycloalkyl, substituted cycloalkyl, phenyl or halophenyl, R.sup.5 is cycloalkyl, cycloalkylalkyl or alkyl, B is a sulphur atom or a sulfinyl or sulfonyl group and A is the group ##STR15## in which R.sup.6, R.sup.7 and R.sup.8 each independently are hydrogen or alkyl, R.sup.9 is hydrogen, alkyl, hydroxyalkyl, amino, alkoxycarbonylamino or benzyloxycarbonylamino, n is the integer zero or one and X is the group Y--CO-- or, where n is the integer one, also the group Z--O--, wherein Y is cycloalkylamino, sulphoalkylamino or bisalkoxyalkylamino, or pyridylalkylamino or morpholino- alkylamino, each of which can be substituted at the amino group by alkyl;
• pyrazinylalkylamino, which can be substituted at the nitrogen atom and/or at the amino group by alkyl;
• 4-piperidinylalkylamino, which can be substituted at the nitrogen atom by alkyl, benzyl, benzyloxycarbonyl, alkoxycarbonyl or hydroxyalkyl and/or at the amino group by alkyl;
• alkoxycarbonylalkylamino, hydroxyalkoxyalkylamino, hydroxyalkylamino, bishydroxyalkylamino, the group (R.sup.a)(R.sup.b)N- in which R.sup.a and R.sup.b each independently are hydrogen or alkyl or together with the nitrogen atom to which they are attached are a saturated 5- or 6-membered heterocyclic ring which can contain an additional nitrogen atom or an oxygen or sulphur atom as a further hetero atom or can carry an oxo group, whereby the sulphur atom can also be present in the form of a sulfinyl or sulfonyl group, or which can be o substituted on one or two carbon atoms by alkyl, hydroxy, hydroxyalkyl or alkoxyalkoxy or on a second nitrogen atom which may be present by alkyl, benzyl, benzyloxycarbonyl, alkoxycarbonyl or hydroxyalkyl, or in which the optionally present second nitrogen atom can carry an oxygen atom, alkoxyalkoxyalkoxy, cycloalkylalkoxy, 1,3-dimethyldioxolan-2-ylalkoxy, the group (R.sup.a)(R.sup.b)N-alkoxy, the residue of a natural aminodesoxy sugar or, where R.sup.9 is different from hydrogen or alkyl, also alkoxy and Z is C.sub.5 -C.sub.17 -alkylcarbonyl, benzoyl, alkoxyalkylcarbonyl, cycloalkylcarbonyl, aminoalkylcarbonyl which can be substituted at the nitrogen atom by alkoxycarbonyl or benzyloxycarbonyl, alkylaminocarbonyl, phenylaminocarbonyl or, where R.sup.9 is different from hydrogen or alkyl, also hydrogen, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as pharmaceutically usable salts of these compounds.