US 5,393,790 A · Substituted spiro compounds for the treatment of inflammation

Abstract

A class of substituted spiro compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula III: ##STR1## wherein n is a number selected from 0, 1 and 2; wherein R.sup.3 is methylsulfonyl or sulfamyl; and wherein R.sup.8 is selected from hydrido, fluoro, chloro, bromo, iodo, methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, methoxy, ethoxy, propoxy, butoxy, hydroxyl, mercapto, methylthio, ethylthio, cyano, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, trifluoromethoxy, hydroxymethyl, methoxymethyl and ethoxymethyl; or a pharmaceutically-acceptable salt thereof.

Claims41

Dependent claims

A compound of Formula I ##STR33## wherein A is selected from ##STR34## wherein each of R.sup.1 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, haloalkoxy, hydroxyalkyl, alkoxyalkyl, hydroxyl, mercapto, alkylsulfonyl, haloalkylsulfonyl and sulfamyl;

and wherein n is a number selected from 0, 1, 2 and 3;
or a pharmaceutically-acceptable salt thereof.

A compound of Formula II ##STR35## wherein each of R.sup.1 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, haloalkoxy, hydroxyalkyl, alkoxyalkyl, hydroxyl, mercapto, alkylsulfonyl, haloalkylsulfonyl and sulfamyl;

and wherein n is a number selected from 0, 1, 2 and 3;
or a pharmaceutically-acceptable salt thereof.

A compound of Formula IV ##STR37## wherein n is a number selected from 0, 1, 2 and 3;and wherein each of R.sup.1 through R.sup.5 and R.sup.7 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, hydroxyalkyl, alkoxyalkyl, hydroxyl, mercapto, alkylsulfonyl and sulfamyl;

or a pharmaceutically-acceptable salt thereof.

A compound of Formula V ##STR38## wherein n is a number selected from 0, 1, 2 and 3;

and wherein each of R.sup.1 through R.sup.6 and R.sup.8 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, hydroxyalkyl, alkoxyalkyl, hydroxyl, mercapto, alkylsulfonyl and sulfamyl;
or a pharmaceutically-acceptable salt thereof.

A compound of Formula VI ##STR39## wherein n is a number selected from 0, 1, and 3;

and wherein each of R.sup.1 through R.sup.7, R.sup.9 and R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, hydroxyalkyl, alkoxyalkyl, hydroxyl, mercapto, alkylsulfonyl and sulfamyl;
or a pharmaceutically-acceptable salt thereof.

Dependencies are inferred from the claim text.

Substituted spiro compounds for the treatment of inflammation

Life of this patent

Substituted spiro compounds for the treatment of inflammation

Life of this patent

Abstract

Claims41