Phenylethanolamines, pharmaceutical compositions containing these compounds and process for preparing them
OwnerHelmut Pieper, Gunther Engelhardtinventors
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Abstract
The invention relates to phenylethanolamines of general formula ##STR1## wherein R.sub.1 and R.sub.2 are defined as in claim 1, the enantiomers and the acid addition salts thereof, which have valuable pharmacological properties, not only analgesic, antiphlogistic, broncholytic, uterus-spasmolytic, lipolytic effects and an antispastic effect on the cross-striped muscle, but also .beta..sub.2 -mimetic and/or .beta..sub.1 -blocking effects, the use thereof as pharmaceuticals and as performance enhancers and processes for preparing them.
Claims6
A phenylethanolamine of formula ##STR7## wherein R.sub.1 is hydrogen, or a carbonyl group substituted by C.sub.1 -C.sub.4 alkoxy
- R.sub.2 is a group of formula ##STR8## wherein m is an integer from 2 to 8,
- n is an integer from 1 to 7,
- R.sub.3 and R.sub.4, which may be identical or different, are hydrogen, fluoro, chloro, bromo, methyl, ethyl, hydroxy, methoxy or ethoxy or
- R.sub.3 and R.sub.4 together are methylenedioxy or ethylenedioxy or a pharmaceutically acceptable acid addition salt thereof.
1-(4-e thoxycarbonylamino-3-cyano-5-fluoro-phenyl)-2-[6-(4-phenylbutoxy)hexylamino ]-ethanol or a pharmaceutically acceptable acid addition salt thereof.
1-(4-amino-3-cyano-5-fluoro-phenyl)-2-[6-(4-phenylbutoxy)-hexylamin o]-ethanol or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.