Anti-fungal triazole derivatives
AssigneeSankyo Company, Limited
InventorsSadao Oida, Takeo Miyaoka, Yawara Tajima, Toshiyuki Konosu, Noriko Takeda, Hiroshi Yasuda
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Abstract
Compounds of formula (I): ##STR1## in which: Ar is optionally substituted phenyl; R.sup.1 is alkyl; R.sup.2 is substituted alkyl or substituted cycloalkyl; and n is 0, 1 or 2; and pharmaceutically acceptable salts and esters thereof have valuable anti-fungal properties and can be used for pharmaceutical and veterinary treatment. Methods of preparing these compounds are also provided.
Claims7
A compound selected from the group consisting of 3-(cyanomethylsulfonyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2 -butanol and pharmaceutically acceptable salts thereof.
A compound selected from the group consisting of 3-[(1-cyanoethyl)thio]-2-(4-chlorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-buta nol and pharmaceutically acceptable salts thereof.
A compound selected from the group consisting of 2-(4-chlorophenyl)-3-[(1-methoxyethyl)thio]-1-(1H-1,2,4-triazol-1-yl)-2-bu tanol and pharmaceutically acceptable salts thereof.
A compound selected from the group consisting of 2-(2,4-difluorophenyl)-3-[(1-methoxyethyl)thio]-1-(1H-1,2,4-triazol-1-yl)- 2-butanol and pharmaceutically acceptable salts thereof.
A compound selected from the group consisting of 3-(cyanomethylsulfinyl)-2-(2,4-difluorophenyl) -1-(1H-1,2,4-triazol-1-yl) -2-butanol and pharmaceutically acceptable salts thereof.
A pharmaceutical or veterinary composition for the treatment or prophylaxis of fungal infections, which comprises an effective antifungal amount of an anti-fungal agent in admixture with a pharmaceutically or veterinarily acceptable carrier or diluent, wherein the anti-fungal agent is at least one compound selected from the group consisting of 3-(cyanomethylsulfonyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2 -butanol;
- 3-((1-cyanoethyl)thio)-2-(4-chlorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-buta nol;
- 2-(4-chlorophenyl)-3-((1-methoxyethyl)thio)-1-(1H-1,2,4-triazol-1-yl)-2-bu tanol;
- 2-(2,4-difluorophenyl)-3-((1-methoxyethyl)thio)-1-(1H-1,2,4-triazol-1-yl)- 2-butanol;
- 3-(cyanomethylsulfinyl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)- 2-butanol and pharmaceutically acceptable salts.
A method for the treatment or prophylaxis of fungal infections in an animal, which method comprises administering to said animal an effective anti-fungal amount of an anti-fungal agent, wherein the anti-fungal agent is at least one compound selected from the group consisting of 3-(cyanomethylsulfonyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2 -butanol;
- 3-((1-cyanoethyl)thio)-2-(4-chlorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-buta nol;
- 2-(4-chlorophenyl)-3-((1-methoxyethyl)thio)-1-(1H-1,2,4-triazol-1-yl)-2-bu tanol;
- 2-(2,4-difluorophenyl)-3-((1-methoxyethyl)thio)-1-(1H-1,2,4-triazol-1-yl)- 2-butanol;
- 3-(cyanomethylsulfinyl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)- 2-butanol and pharmaceutically acceptable salts.
Dependencies are inferred from the claim text.