Back to results
US 5,393,763 AGranted
Methods for inhibiting bone loss
AssigneeEli Lilly and Company
InventorsLarry J. Black, George J. Cullinan
Life of this patent
Estimating the term…
Abstract
The current invention provides methods and pharmaceutical formulations that are useful for inhibiting the loss of bone. These methods and formulations can be used without the associated adverse effects of estrogen therapy, and thus serve as an effective and acceptable treatment for osteoporosis.
Claims35
A method of inhibiting bone loss comprising administering to a human in need of treatment an amount of a compound of Formula I ##STR11## wherein X is a bond, CH.sub.2, or CH.sub.2 CH.sub.2 ;
- R and R.sup.1, independently, are hydrogen, hydroxyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -acyloxy, C.sub.1 -C.sub.6 -alkoxy-C.sub.2 -C.sub.6 -acyloxy, R.sup.3 -substituted aryloxy, R.sup.3 -substituted aroyloxy, R.sup.4 -substituted carbonyloxy, chloro, or bromo;
- R.sup.2 is a heterocyclic ring selected from the group consisting of pyrrolidino, piperidino, or hexamethyleneimino;
- R.sup.3 is C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 -alkoxy, hydrogen, or halo;
- and
- R.sup.4 is C.sub.1 -C.sub.6 -alkoxy or aryloxy;
- or a pharmaceutically acceptable salt thereof, that is effective to inhibit bone loss in a human.
3 more elements
Dependencies are inferred from the claim text.