Isochromane derivatives

An isochromane compound of the formula ##STR6## in which n=1-4 and R.sub.1 is one to four substituents independently selected from the group consisting of hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, CF.sub.3, and, when R.sub.l comprises two adjacent substituents, a methylenedioxy group;

• R.sub.2 is one to four substituents independently selected from the group consisting of hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, CF.sub.3, and, when R.sub.2 comprises two adjacent substituents, a methylenedioxy group;
• R.sub.3 is one to four substituents independently selected from the group consisting of hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, CF.sub.3, and, when R.sub.3 comprises two adjacent substituents, a methylenedioxy group;
• R.sub.4 is selected from hydrogen or alkyl (1-4 C);
• A is a bond or an alkylene or alkylidene group with 1-6 carbon atoms;
• Y is selected from the group consisting of a bond, O, S, and NR.sub.5 ;
• B is an alkylene or alkylidene group with 1-6 carbon atoms when Y is a bond, or B is an alkylene group with 2-6 carbon atoms when Y is selected from the group consisting of O, S, and NR.sub.5 ;
• and
• R.sub.5 is selected from hydrogen or alkyl (1-4 C);
• or a pharmaceutically acceptable salt thereof.