Substituted azetidinylpyridone naphthyridine carboxylic acid derivatives and their application as medical products
AssigneeLaboratorios Del Dr. Esteve, S.A.
InventorsAugusto C. Pinol, Jordi F. Constansa, Juan P. Corominas
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Abstract
The present invention relates to new azetidine derivatives of substituted azetidinylpyridonecarboxylic acids, of 1,4-dihydro-4-oxo-3-quinolinecarboxylic, 4-oxo-1,8-naphthyridine-3-carboxylic and 2,3-dihydro-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids, represented by the general formula I: ##STR1## The present invention also relates to therapeutically acceptable salts of these compounds, a process for preparing them and their application as medicinal products.
Claims7
The compounds which correspond to the formula I ##STR5## in which R.sub.1 represents a lower alkyl radical, a lower haloalkyl radical, an aryl radical or an aryl radical substituted with one or more fluorine atoms(s);
- R.sub.4 represents an amino radical;
- R.sub.3, R.sub.6 and R.sub.7 each represent a hydrogen atom;
- R.sub.2 and R.sub.5 represent a hydrogen atom or a lower alkyl radical, provided that one of R.sub.2 and R.sub.5 represent a hydrogen atom and the other represents a lower alkyl radical;
- R.sub.8 represents a hydrogen atom, a nitro radical or an amino radical;
- and
- R.sub.10 represents a hydrogen atom or a C.sub.1 to C.sub.4 lower alkyl radical;
- wherein the azetidine substituents can have, depending on the number, nature and relative position of the substituents, up to three chiral centers, each of them with an "R" or "S" configuration;
- as well as their physiologically acceptable salts with inorganic acids, or with organic acids.
Dependencies are inferred from the claim text.