Polycyclic guanine derivatives

A compound of the formula:

• ##STR126## wherein J is oxygen or sulfur,
• R.sup.1 is hydrogen, alkyl or alkyl substituted with aryl or hydroxy;
• R.sup.2 is hydrogen, aryl, heteroaryl, cycloalkyl, alkyl or alkyl substituted with aryl, heteroaryl, hydroxy, alkoxy, amino, monoalkyl amino or dialkylamino, or --(CH.sub.2).sub.m TCOR.sup.20 wherein m is an integer from 1 to 6, T is oxygen or --NH-- and R.sup.20 is hydrogen, aryl, heteroaryl, alkyl or alkyl substituted with aryl or heteroaryl;
• R.sup.3 is hydrogen, halo, trifluoromethyl, alkoxy, alkylthio, alkyl, cycloalkyl, aryl, aminosulfonyl, amino, monoalkylamino, dialkylamino, hydroxyalkylamino, aminoalkylamino, carboxy, alkoxycarbonyl or aminocarbonyl or alkyl substituted with aryl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino;
• R.sup.a, R.sup.b, R.sup.c and R.sup.d independently represent hydrogen, alkyl, cycloalkyl or aryl;
• or (R.sup.a and R.sup.b) or (R.sup.c and R.sup.d) or (R.sup.b and R.sup.c) can complete a saturated ring of 5- to 7-carbon atoms, or (R.sup.a and R.sup.b) taken together and (R.sup.b and R.sup.c) taken together, each complete a saturated ring of 5- to 7-carbon atoms, wherein each ring optionally can contain a sulfur or oxygen atom and whose carbon atoms may be optionally substituted with one or more or the following:
• alkenyl, alkynyl, hydroxy, carboxy, alkoxycarbonyl, alkyl or alkyl substituted with hydroxy, carboxy or alkoxycarbonyl;
• or such saturated ring can have two adjacent carbon atoms which are shared with an adjoining aryl ring;
• and
• n is zero or one.