Methylpiperazinoazepine compounds, preparation and use thereof
AssigneeTherabel Research S.A./N.V.
InventorsJean-Francois F. Liegeois, Jacques E. Delarge
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Abstract
Methylpiperazinoazepine derivatives corresponding to formula (I): ##STR1## wherein the symbols X, R.sub.1, R.sub.2, N.sub.1 and N.sub.2 have different meanings and pharmaceutically acceptable salts thereof, preparation and use thereof.
Claims17
A methylpiperazinoazepine compound corresponding to formula (I) or a pharmaceutically acceptable salt thereof:
- ##STR13## wherein:
- X represents an oxygen atom, a sulfur atom, a selenium atom or NH- or NR.sub.3 -group wherein R.sub.3 represents a ##STR14## group or a straight or branched alkyl group of 1 to 4 carbon atoms;
- R.sub.1 represents a hydrogen atom, a halogen atom or a straight or branched alkyl group of 1 to 4 carbon atoms;
- R.sub.2 represents a hydrogen atom, a halogen atom or a straight or branched alkyl group of 1 to 4 carbon atoms;
- and
- N.sub.1 represents a benzene ring and N.sub.2 a pyridine ring or vice versa, wherein the nitrogen atom of the pyridine ring is in the b, b', d or d' position, and with the proviso that, when R.sub.1 and R.sub.2 represent hydrogen and X represents sulfur, oxygen or an NH-group, N.sub.1 is pyridine and N.sub.2 is benzene and the pyridine nitrogen is excluded from position d', both N.sub.1 and N.sub.2 can be benzene when X represents a selenium atom, and both N.sub.1 and N.sub.2 can be pyridine when X represents a sulfur atom.
6-(4-methylpiperazin-1-yl)pyrido(2,3-b)benzo-1,4-thiazepine.
6-(4-methylpiperazin-1-yl)pyrido(2,3-b)benzo-1,4-oxazepine fumarate.
6-(4-methylpiperazin-1-yl)-11H-pyrido(2,3-b)benzo-1,4-diazepine.
10-(4-methylpiperazin-1-yl)pyrido(4,3-b)benzo-1,4-thiazepine.
6-(4-methylpiperazin-1-yl)dipyrido(2,3-b:
- 3',2'-f)1,4-thiazepine.
Dependencies are inferred from the claim text.