Substituted dibenzoxazepine compounds for the treatment of convulsions, ischemia and other diseases responsive to prostaglandin-E.sub.2 antagonists

A method for treating convulsions in a mammal comprising administering to said mammal a therapeutically-effective amount of a compound having the formula:

• ##STR58## or a pharmaceutically-acceptable salt thereof, wherein:
• Y is oxygen, sulfur, ##STR59## R.sup.1 is hydrogen, halogen or --CF.sub.3 ;
• R.sup.2 is hydrogen, halogen, --OH or --OCH.sub.3 ;
• R.sup.3 is hydrogen, alkyl, aryl, alkyl-substituted aryl or aryl-substituted alkyl;
• m is an integer of from 1 to 5;
• X is ##STR60## R.sup.4 is hydrogen, alkyl, aryl, alkyl-substituted aryl, trifluoromethyl-substituted aryl or aryl-substituted alkyl;
• and
• R.sup.5 and R.sup.6 are each independently hydrogen, alkyl, aryl, alkyl-substituted aryl or aryl-substituted alkyl.

A method for treating ischemia in a mammal comprising administering to said mammal a therapeutically-effective amount of a compound having the formula:

• ##STR61## or a pharmaceutically-acceptable salt thereof, wherein:
• Y is oxygen, sulfur, ##STR62## R.sup.1 is hydrogen, halogen or --CF.sub.3 ;
• R.sup.2 is hydrogen, halogen, --OH or --OCH.sub.3 ;
• R.sup.3 is hydrogen, alkyl, aryl, alkyl-substituted aryl or aryl-substituted alkyl;
• m is an integer of from 1 to 5;
• X is ##STR63## R.sup.4 is hydrogen, alkyl, aryl, alkyl-substituted aryl, trifluoromethyl-substituted aryl or aryl-substituted alkyl;
• and
• R.sup.5 and R.sup.6 are each independently hydrogen, alkyl, aryl, alkyl-substituted aryl or aryl-substituted alkyl.