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US 5,393,741 AGranted
Acetal derivatives of aromatic aldehydes
AssigneeNorsk Hydro a.s.
InventorsErik O. Pettersen, Rolf O. Larsen, Bernt Borretzen, John M. Dornish, Reidar Oftebro
Life of this patent
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Abstract
New compounds having the general formula I ##STR1## wherein Y may be H or D; and A is H, D, alkyl with 1-4 C-atoms, halogen, nitro, amino, monoalkyl amino or dialkyl amino wherein the alkyl groups have 1-4 C atoms or OR wherein R is H or alkyl of 1-4 C-atoms; X.sub.1 and X.sub.2 may together with the carbon atom to which they are bound form a cyclic acetal, thioacetal, dithiane, aminal, oxazolidine or thiazolidine; or pharmaceutically acceptable salts thereof. The compounds are useful as anti-carcinoma agents.
Claims5
A compound of formula IIIa, IIIaa or IIIab:
- ##STR10## wherein:
- Y is H or D;
- A is H, D, alkyl with 1-4 C-atoms, halogen, nitro, amino, monoalkylamino or dialkylamino wherein the alkyl groups have 1-4 C atoms, or OR wherein R is H or alkyl
- of 1-4 C-atoms;
- n is 0 or 1;
- m is an integer of 1-4;
- and
- either R.sub.1 and R.sub.3 together with the C atoms to which they are bound form a sugar molecule and R.sub.5 is H, OH, alkyl with 1-4 carbon atoms which may be unsubstituted or substituted or phenyl which may be unsubstituted or substituted, or R.sub.3, and R.sub.5 together with the C atoms to which they are bound form a sugar molecule and R.sub.1 is H, OH, alkyl with 1-4 carbon atoms Which may be unsubstituted or substituted or phenyl which may be unsubstituted or substituted;
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.