Use of bone morphogenetic protein in synergistic combination with TGF-.beta. for bone repair
AssigneeCeltrix Pharmaceuticals, Inc.
InventorsHanne Bentz, Andrea Y. Thompson, Rosa Armstrong, David M. Rosen
Life of this patent
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Abstract
Bone morphogenetic proteins -2 and -3 (BMPs -2 and -3) work in synergistic combination with TGF-.beta.z to provide compositions with increased osteogenic activity. Methods of treating bone defects, inducing bone growth and increasing bone marrow cell production using these compositions are also disclosed.
Claims4
A composition for treating cartilage and/or bone defects consisting essentially of:
- bone morphogenetic protein-2 (BMP-2), bone morphogenetic protein-3 (BMP-3), transforming growth factor-.beta.2 (TGF-.beta.2) together in a tissue-growth-inducing amount;
- and a pharmaceutically acceptable carrier or excipient.
An osteogenic composition for inducing bone growth consisting essentially of:
- bone morphogenetic protein-2 (BMP-2), bone morphogenetic protein-3 (BMP-3), and transforming growth factor-.beta.2 (TGF-.beta.2) together in a bone-growth-inducing amount;
- and a pharmaceutically acceptable carrier or excipient.
A method for treating bone and cartilage formation in an individual having a cartilage or bone defect comprising:
- administering to the individual a composition consisting essentially of bone morphogenetic protein-2 (BMP-2), bone morphogenetic protein-3 (BMP-3) and transforming growth factor-.beta.2 (TGF-.beta.2) together in a tissue-growth-inducing amount, and a pharmaceutically acceptable carrier or excipient.
A method for inducing bone marrow cell production in an individual comprising:
- administering to the individual a composition consisting essentially of bone morphogenetic protein-2 (BMP-2), bone morphogenetic protein-3 (BMP-3) and transforming growth factor-.beta.2 (TGF-.beta.2) together in a bone marrow cell growth-inducing amount, and a pharmaceutically acceptable carrier or excipient.
Dependencies are inferred from the claim text.