Cytotoxic drug conjugates for treatment of neoplastic diseases
AssigneeHealth Research, Inc.
InventorsGeorge L. Mayers, Jafar Razeq, Mahmoud M. Abu-Hadid
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Abstract
A novel composition of matter comprising a ligand-carbohydrate-cytotoxic drug conjugate is produced by the steps of (1) reacting a carbohydrate with a ligand, (2) reacting the product of step (1) with a cytotoxic drug, and (3) stabilizing the product of step (2) by reduction. The composition is used for treating a neoplastic disease by a process of administering a non-toxic, effective amount of a ligand-carbohydrate-cytotoxic drug conjugate to a human being or animal in need of such a treatment.
Claims48
A composition of matter comprising a ligand-carbohydrate-cytotoxic drug conjugate wherein the carbohydrate has a molecular weight between 50,000 and 40 million and contains sufficient branching and sufficient adjacent hydroxyl group moieties such that at least 100 cytotoxic drug residues are attached to the carbohydrate.
Dependencies are inferred from the claim text.