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US 5,393,666 AGranted
Method of activating prothrombin
AssigneeImmuno Aktiengesellschaft
InventorYendra Linnau
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Abstract
There is disclosed a method of activating prothrombin by means of trypsin, wherein the prothrombin is recovered from a blood or plasma fraction, treated with trypsin immobilized on a water-insoluble carrier, and separated from the immobilized trypsin after activation.
Claims4
A method of activating prothrombin comprising the steps of:
- providing a blood or plasma fraction containing prothrombin,
- recovering said prothrombin from said fraction containing prothrombin,
- contacting said prothrombin with immobilized trypsin to activate said prothrombin, wherein said activation of said prothrombin is carried out at a pH of 5.8 to 7.9, a conductivity of 5 to 25 mS and a temperature of 2.degree. to 45.degree. C. and whereby thrombin is formed, and
- separating said immobilized trypsin after the formation of said thrombin.
1 more element
A method for activating prothrombin to form thrombin, comprising the step of contacting said prothrombin with immobilized trypsin wherein said contacting occurs at a pH of 5.8 to 7.9, a conductivity of 5 to 25 mS and a temperature of 2.degree. to 45.degree. C.
Dependencies are inferred from the claim text.