Pharmaceuticals microencapsulated by vapor deposited polymers and method
AssigneeRonald T. Dodge Co.
InventorRonald J. Versic
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Abstract
A microencapsulated pharmaceutical is formed by vapor depositing a polymeric film about an active pharmaceutical agent. The film thickness of the vapor deposited film is controlled to provide effective controlled release of said pharmaceutical agent subsequent to application. In a preferred embodiment the pharmaceutical is an orally ingestible pharmaceutical formed by vapor deposition of a poly-p-xylylene polymer about a core comprising an active pharmaceutical agent. The pharmaceutical agent exhibits surprising controlled release activity inspite of the extreme inertness of vapor deposited films such as Parylene films.
Claims2
A method of forming a pharmaceutical comprising:
- coating an inert core material with a vapor deposited polymeric film in combination with minute particles of an active pharmaceutical agent, and subsequently coating said particles of active pharmaceutical agent with a vapor deposited polymeric film, said polymeric film being the solid polymerization product of pyrolyzed vapors of di-p-xylylene, said product having the general repeating units ##STR3## wherein R is an aromatic nuclear substituent, x is a number from 0 to 3 and n is a number from 10-10000 and said polymeric film having a thickness of from about 0.1 microns to about 10 microns.
Dependencies are inferred from the claim text.