Copolymers of N-vinyl-lactams suitable for oligomer solid phase synthesis
AssigneeIsis Pharmaceuticals, Inc.
InventorDouglas J. Dellinger
Life of this patent
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Abstract
Crosslinked copolymers of N-vinylpyrrolidone and other n-vinyl-lactam monomers and ethylenically unsaturated monomer having at least one amine or amine-displaceable functionality are utilized for oligomer synthesis. The oligomer of interest is connected to the polymer via a connection to an amine function. A spacer can be included between the amine function and the polymeric backbone.
Claims20
A solid support for oligomer synthesis having free amine functionalities comprising a polymerized blend of:
- from about 10 to about 90 percent by weight of N-vinyl lactam;
- from about 10 to about 90 percent by weight of ethylenically unsaturated monomer having at least one amine or amine-displaceable functionality, said ethylenically unsaturated monomer comprising an amino or alkylamino moiety linked to styrene via a C.sub.1 -C.sub.10 alkyl moiety;
- and
- from about 0.01 to about 5 percent by weight of di- or polyfunctional crosslinking agent.
A solid support for oligomer synthesis having free amine functionalities comprising a polymerized blend of:
- from about 10 to about 90 percent by weight of N-vinyl lactam;
- from about 10 to about 90 percent by weight of ethylenically unsaturated monomer having at least one amine or amine-displaceable functionality;
- and
- from about 0.01 to about 5 percent by weight of di- or polyfunctional crosslinking agent, said di- or polyfunctional crosslinking agent being divinylbenzene or a divinyl ether.
A solid support for oligomer synthesis comprising a polymerized blend of:
- from about 10 to about 90 percent by weight of N-vinyl pyrrolidone;
- from about 10 to about 90 percent by weight of one of alkylaminoalkylstyrene, aminoalkylstyrene, vinylalkylamine or vinylalkyl(alkylamine);
- and
- from 0.02 to about 4 percent by weight of di- or polyfunctional crosslinking agent.
A solid support for oligomer synthesis comprising a polymerized blend of:
- from about 10 to about 90 percent by weight of N-vinyl pyrrolidone;
- from about 10 to about 90 percent by weight of one of C.sub.1 -C.sub.10 -alkylamino-C.sub.1 -C.sub.10 -alkylstyrene, amino-C.sub.1 -C.sub.10 -alkylstyrene, vinyl-C.sub.1 -C.sub.10 -alkylamine or vinyl-C.sub.1 -C.sub.10 -alkyl (C.sub.1 -C.sub.10 -alkylamine);
- and
- from 0.01 to about 5 percent by weight di- or polyfunctional crosslinking agent.
A solid support for oligomer synthesis comprising a polymerized blend of:
- from about 10 to about 90 percent by weight of N-vinyl pyrrolidone;
- and
- from about 10 to about 90 percent by weight of N-phthalimidoalkyl acrylamide;
- and from 0.01 to about 5 percent by weight crosslinking agent.
A solid support for oligomer synthesis comprising:
- from about 10 to about 90 percent by weight of N-vinylpyrrolidone;
- from about 10 to about 90 percent by weight of aminomethyl acrylamide;
- and
- from about 0.01 to about 5 percent by weight of a divinylbenzene crosslinking agent.
A solid support for oligomer synthesis comprising a first polymer comprising a polymerized blend of:
- from about 10 to about 90 percent by weight of N-vinyl pyrrolidone;
- from about 10 to about 90 percent by weight of chloromethyl styrene;
- and
- from about 0.01 to about 5 percent by weight of a crosslinking agent;
- said first polymer being reacted with an amine to displace the chloride functionalities to provide said solid support having free amine groups.
Dependencies are inferred from the claim text.