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US 5,389,687 AGranted
Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes
AssigneeEli Lilly and Company
InventorsJohn M. Schaus, Robert D. Titus
Life of this patent
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Abstract
The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes which exhibit binding activity at the serotonin 1A receptor.
Claims19
A compound of the formula:
- ##STR10## in which R is allyl;
- R.sup.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, or allyl;
- R.sup.2 is halo;
- and pharmaceutically acceptable acid addition salts thereof.
1 more element
A pharmaceutical formulation which comprises, in association with a pharmaceutically acceptable carrier, diluent, or excipient, a compound of the formula ##STR11## in which R is allyl;
- R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, or allyl;
- R.sub.2 is halo;
- and pharmaceutically acceptable acid addition salts thereof.
A racemate or stereo isomer of the compound of the formula ##STR12## in which R is C.sub.1.sub.C.sub.4 alkyl;
- R.sub.1 is hydrogen or C.sub.1 -C.sub.4 alkyl;
- R.sub.2 is halo;
- and pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.